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THE EXPRESSION AND MEANING OF p27kipl AND ki-67 IN ASTROCYTOMA
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1006-9801.2003.06.005
- Key Word:
- p27kipl蛋白;ki-67标记指数;星形胶质瘤;免疫组织化学;诊断;治疗
Abstract： 目的:检测p27kipl、ki-67在星形胶质瘤中的表达,探讨p27kipl表达与星形胶质瘤分化程度及增生活性的关系.方法:采用免疫组化S-P法检测星形胶质瘤p27kipl、ki-67的表达,应用SAS 8.0统计软件进行数据处理.结果:在高分化星形胶质瘤(Ⅰ级、Ⅱ级)中p27kipl阳性表达率为76.9%,在低分化星形胶质瘤(Ⅲ级、Ⅳ级)中阳性率为50.0%,二者存在显著性差异(x2=4.389,P＜0.05);p27kipl表达水平与病理分级呈负相关关系(rs=-0.487,P＜0.000 1);p27kipl表达水平与ki-67标记指数呈负相关关系(rs=-0.528,P＜0.000 1).结论:p27kipl表达与星形胶质瘤的分化程度负相关.p27kipl对星形胶质瘤增生活性起抑制作用.
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