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MECHANISM OF CURCUMIN INDUCED APOPTOSIS ON NB4 CELLS
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1006-9801.2003.06.004
- Key Word:
- 姜黄素;Caspases3;细胞凋亡
Abstract： 目的:研究姜黄素对急性白血病NB4细胞的诱导凋亡作用,并对其作用机制进行探讨.方法:以不同浓度的姜黄素作用于体外培养的NB4细胞,检测细胞生长抑制率,观察细胞凋亡时的形态学变化,对细胞凋亡前后的Caspase3活性进行检测.结果:姜黄素可显著地提高NB4细胞Caspase3活性,抑制细胞的生长,诱导细胞发生凋亡.并呈现出明显的量-效与时-效关系.结论:姜黄素能诱导NB4细胞调亡,升高Caspase3活性是其重要作用机制之一.
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