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EFFECTS OF TELOMERASE INHIBITOR COMBINED WITH RADIOTHERAPY ON GASTRIC CANCER XENOGRAFT IN MICE
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1006-9801.2003.06.001
- Key Word:
- 胃癌;端粒酶;抑制剂;放射治疗
Abstract： 目的:探讨端粒酶抑制剂对动物在体肿瘤的治疗作用及对放射治疗的增敏价值.方法:将SGC-7901胃癌细胞接种BALB/c小鼠,采用端粒酶抑制剂AZT联合放疗治疗小鼠胃癌,观察其对肿瘤体积和肿瘤端粒酶活性的影响.结果:未治疗组小鼠肿瘤体积增加了2.5倍,而AZT组、放疗组及AZT联合放疗组肿瘤体积分别缩小了26.3%、36.8%及70.5%.肿瘤端粒酶活性检测,未治疗组、AZT组、放疗组及AZT联合放疗组的相对端粒酶活性分别为100、55.2、24.5及12.1.结论:AZT、放疗均能使肿瘤体积缩小并降低端粒酶活性,且AZT能增加肿瘤的放射敏感性.
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