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THE EXPRESSION AND SIGNIFICANCE OF MATRIX METALLOPROTEINASE-2 AND TISSUE INHIBITOR OF METALLOPROTEINASE-2 IN PAPILLARY THYROID CARCINOMA
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1006-9801.2003.05.003
- Key Word:
- 甲状腺乳头状癌;基质金属蛋白酶-2;组织基质金属蛋白抑制剂-2;免疫组织化学;预后
Abstract： 目的:探讨基质金属蛋白酶-2(MMP-2)和组织基质金属蛋白抑制剂-2(TIMP-2)在人甲状腺乳头状癌组织中的表达及其与浸润程度、淋巴结转移的关系.方法:应用免疫组织化学S-P法对56例甲状腺乳头状癌组织及其癌旁正常甲状腺组织中MMP-2和TIMP-2表达情况进行检测.结果:MMP-2和TIMP-2在甲状腺乳头状癌组织中表达的阳性率分别为76.8%(43/56)和37.5%(21/56).在癌旁正常甲状腺组织中表达的阳性率分别为33.9%(19/56)和32.1%(18/56),表明MMP-2在甲状腺乳头状癌中有较高表达率.同时MMP-2和TIMP-2的表达与浸润程度、淋巴结转移有显著相关性(P＜0.05),与肿瘤大小无相关性.结论:MMP-2和TIMP-2的表达与甲状腺乳头状癌浸润程度、淋巴结转移密切相关,可作为判断甲状腺乳头状癌生物学行为和预后的参考指标.
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