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EXPRESSION AND SIGNIFICANCE OF HEAT SHOCK PROTEIN 70 IN ASTROCYTOMA
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1006-9801.2003.05.001
- Key Word:
- 凋亡;HSP70;星形细胞瘤;免疫组织化学
Abstract： 目的:研究热休克蛋白70(HSP70)在星形细胞瘤(astrocytoma)中的表达与意义.方法:采用鼠抗人HSP70单克隆抗体及免疫组织化学SABC法.结果:在99例星形细胞瘤中,HSP70表达70例(70.7%);用于对照的正常脑组织中,HSP70阳性仅1例(10%).HSP70在星形细胞瘤中的表达强于正常对照组(P＜0.05),HSP70在Ⅰ级和Ⅱ级、Ⅱ级和Ⅲ级、Ⅲ级和Ⅳ级星形细胞瘤相互之间表达无显著性差异(P＞0.05),但在50例低度恶性星形细胞瘤(WHO Ⅰ级～Ⅱ级)中表达强于在49例高度恶性星形细胞瘤(WHOⅢ级～Ⅳ级)中的表达(P＜0.05).结论:HSP70在大部分星形细胞瘤中有不同程度表达,HSP70可能参与星形细胞瘤的凋亡调变;其表达与星形细胞瘤分化有关.
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