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Study on the Correlation between the Expression of p53 and MDR in Lung Cancer
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1006-9801.2002.01.006
- Key Word:
- 肺癌;p53蛋白;mdr-1、mrp;表达关系
Abstract： 目的：探讨p53蛋白与肺癌多药耐药(MDR)的关系。方法：运用S-P免疫组化法和反转录-聚合酶链反应(RT-PCR)技术，对40例肺癌组织中p53蛋白、多药耐药(mdr-1)基因和多药耐药相关蛋白(mrp)基因表达进行检测。结果：癌组织p53阳性的mdr-1、mrp阳性率高于p53阴性者(P＜0.05)；p53和mdr-1、mrp阳性率与肺癌的病理分期、组织学类型、分化程度和淋巴结转移无关(P＞0.05)，但它们在低分化肿瘤和淋巴结转移标本的阳性率高于中高分化和无淋巴结转移者。结论：p53蛋白对肺癌细胞的mdr-1、mrp表达可能起调控作用，促使肺癌细胞MDR的产生。
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