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THE MODULATION ON TELOMERASE ACTIVITY OF GASTRIC CANCER CELL LINE BY SEVERAL THERAPEUTIC DRUGS

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Author:
No author available
Journal Title:
CANCER RESEARCH AND CLINIC
Issue:
6
DOI:
10.3760/cma.j.issn.1006-9801.2001.06.004
Key Word:
端粒酶;胃肿瘤;化疗药物

Abstract: 目的:研究常用化疗药物对SGC-7901人胃癌细胞株端粒酶活性的调节作用,探讨端粒酶作为化疗敏感性指标的可行性.方法:选择顺铂、丝裂霉素C、阿霉素及5-氟尿嘧啶和甲酰四氢叶酸处理胃癌细胞,采用半定量TRAP-银染法检测药物处理前后的端粒酶活性,流式细胞学检测细胞周期和细胞凋亡率.结果:顺铂、丝裂霉素C和阿霉素在诱导SGC-7901细胞凋亡的同时,下调端粒酶活性,且抑制作用呈时间依赖关系,5-氟尿嘧啶和甲酰四氢叶酸对端粒酶活性无明显抑制作用.结论:观测细胞株端粒酶的活性变化可作为化疗药物敏感性的指标,可合理选择新的化疗药物.

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