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CLINICAL EVALUATION OF CIRCULATING SERUM SIALYL TN ANTIGEN LEVELS IN PATIENTS WITH EPITHELIAL OVARIAN CANCER
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1006-9801.2001.05.006
- Key Word:
- 上皮性卵巢肿瘤;Sialyl Tn抗原;评估
Abstract： 目的:对上皮性卵巢肿瘤患者血浆中STN水平进行评估.方法:选用54例卵巢癌患者,以50例健康非孕妇女、12例妊娠妇女、76例其他妇科良性疾病妇女作为对照,通过放免方法对血清中STN水平进行检测.结果:卵巢癌患者血清STN水平升高者为53.7%,在健康妇女中仅4%,在妇科良性疾病患者中为10.5%,妊娠妇女为0.在研究组和对照组之间存在着显著差异(P＜0.001).卵巢癌患者的STN水平为(109.2±146.4)×103U/L,并且随卵巢癌临床分期的增加,抗原水平及检出阳性率也增加.按组织学类型则阳性率最高的是黏液性囊腺癌(63.3%).结论:由于STN抗原对卵巢癌的检测敏感性、特异性、阳性预测值、阴性预测值均较高,并且有较低的假阳性率,故STN抗原可作为卵巢癌检测的又一可靠指标.
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