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EFFECTS OF GASTRIN ON HUMAN COLONIC CARCINOMA SW480 IN NUDE MICE WITH FLOW CYTOMETRY DETECTION
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1006-9801.2001.05.004
- Key Word:
- 结肠癌;裸鼠;移植瘤;胃泌素;流式细胞术
Abstract： 目的:探讨胃泌素对人结肠癌裸鼠移植瘤的影响.方法:建立人结肠癌SW480裸鼠移植瘤模型,实验动物分为5肽胃泌素(PG)组及对照组,观察PG对移植瘤体积、重量的影响并进行流式细胞术分析.结果:移植瘤的体积重量、细胞内DNA、蛋白质含量、S期、G2M期细胞数、增殖指数PG组显著高于对照组,而G0/G1期细胞数则显著低于对照组.结论:胃泌素在体内具有促进人结肠癌SW480细胞分裂和增殖的作用,为结肠癌患者施行内分泌治疗提供了实验依据.
- [1]R, Osieka,D P, Houchens,A, Goldin,etc.Chemotherapy of human colon cancer xenografts in athymic nude mice.[J].1977,40.