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THE CLINICAL SIGNIFICANCE OF EXPRESSION OF p16 IN GASTRIC CARCINOMA
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1006-9801.2001.04.007
- Key Word:
- 胃癌;p16蛋白;免疫组织化学
Abstract： 目的:观察p16蛋白在胃癌中的表达规律及其与预后的关系.方法:应用免疫组织化学S-P法,对62例有随访结果的胃癌组织进行p16蛋白检测.结果:有淋巴结转移组p16蛋白阳性率18.9%显著低于无淋巴结转移组48.0%(P＜0.05);p16蛋白阳性组胃癌患者术后5年生存率31.6%(6/19)显著高于p1 6蛋白阴性组9.3%(4/43)(P＜0.05).结论:p16蛋白表达状况可作为临床判断胃癌生物学行为、转移潜能及患者预后的一项重要指标.
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