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PRELIMINARY STUDY ON THE EXPRESSION OF SURVIVIN PROTEIN IN CERVICAL INTRAEPITHELIAL NEOPLASIA AND CERVICAL CARCINOMA
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1006-9801.2001.04.005
- Key Word:
- Survivin基因;宫颈上皮内瘤样变;宫颈癌;免疫组化
Abstract： 目的:探讨Survivin基因表达与宫颈癌发生发展的关系.方法:应用免疫组化技术(SP法),检测Strvivin基因在10例正常宫颈组织、5例上皮内瘤样变及59例宫颈鳞癌中的表达.结果:Survivin在正常宫颈组织中不表达,在宫颈上皮癌变过程中表达阳性率逐级升高.Survivin表达阳性率与宫颈癌的组织学分级和临床分期呈正相关.结论:Survivin基因表达发生在宫颈癌恶性转化的早期,并为宫颈癌预后提供了有价值的判断指标.
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