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ANTIANGIOGENESIS STUDY OF ROQUINIMEX IN TREATMENT OF HUMAN COLORECTAL CANCER
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1006-9801.2001.04.004
- Key Word:
- Roquinimex;大肠癌;抗血管生成作用
Abstract： 目的:观察Roquinimex对人大肠癌细胞系SW1116的体内抑瘤效应,并探讨其可能的作用机制.方法:建立人大肠癌裸鼠移植瘤模型,比较各剂量Roquinimex的押瘤效应的强弱.同时运用免疫组化方法,检测人大肠癌裸鼠移植瘤块的瘤灶内微血管密度(MVD),并观察Roquinimex对鸡胚尿膜囊血管生长的影响.结果:体内实验显示Roquinimex能明显抑制SW1116裸鼠移植瘤的生长,各剂量Roquinimex治疗组的瘤块平均体积均小于空白对照组(P＜0.01).各剂量Roquinimex治疗组瘤块微血管密度明显低于未经治疗组(P＜0.05).在鸡胚尿膜囊血管生长模型中,Roquinomex明显抑制了鸡胚尿膜囊血管的生长.结论:Roquinmex能明显降低瘤块内微血管密度,抑制人大肠癌裸鼠移植瘤的体内生长,是一种有效的血管生长抑制剂.
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