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EXPRESSION AND SIGNIFICANCE OF Ki-67 IN GLIOBLASTOMA
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- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1006-9801.2001.03.007
- Key Word:
- 胶质母细胞瘤;预后;Ki-67;MIB-1;标记指数;免疫组化;COX比例风险模型
Abstract： 目的:探讨Ki-67抗原在人脑胶质母细胞瘤中的表达及其预后作用.方法:使用S-P免疫组化方法检测31例人脑胶质母细胞瘤标本中Ki-67抗原的表达.单因素使用Kaplan-Meier法,多因素分析使用COX比例风险模型进行预后分析.结果:Ki-67 LI为(8.07±3.84)%.单因素及多因素分析均显示Ki-67指数是独立的预后因素.Ki-67指数≤2.5%与＞2.5%的患者生存期分别为(46.17±17.21)月、(12.43±5.01)月,P＜0.01.结论:在人脑胶质母细胞瘤中,Ki-67指数不同,其预后也有显著不同.Ki-67指数＞2.5%提示预后较差.
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