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RELATIONSHIPS BETWEEN p53 GENE MUTATION AND SERUM p53 ANTIBODIES IN COLORECTAL CANCER AND THEIR CLINICAL SIGNIFICANCE

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Author:
No author available
Journal Title:
CANCER RESEARCH AND CLINIC
Issue:
2
DOI:
10.3760/cma.j.issn.1006-9801.2001.02.006
Key Word:
大肠肿瘤;基因;p53;聚合酶链反应;酶联免疫吸附分析;免疫组化

Abstract: 目的:研究大肠癌患者血清p53-Ab与p53基因突变及蛋白表达之间的关系及临床意义.方法:运用ELISA法检测34例大肠癌患者及10例健康人血清p53-Ab,同时运用聚合酶链反应一单链构象多态性分析(PCR-SSCP)和免疫组化(IHC)分别检测p53第5-8外显子突变及蛋白表达状况.结果:大肠癌中血清p53-Ab阳性率为17.6%(6/34),正常对照组血清阴性.p53基因突变率及蛋白表达率分别为52.9%(18/34)和55.9%(19/34),大肠正常粘膜未见p53基因突变及蛋白表达.p53基因突变及蛋白表达与p53-Ab存在及临床病理因素无关(P>0.05).结论:p53基因突变是参与和影响p53蛋白表达的主要因素,p53蛋白表达可诱导p53-Ab产生,但不是唯一决定因素.检测血清p53-Ab有助于大肠癌的诊断及高危人群普查.

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