You Position: Home > Paper
EXPRESSION OF p53 AND MDM2 PROTEIN IN HUMAN GIANT CELL TUMORS OF BONE
( views:263, downloads:12 )
- Author:
- No author available
- Journal Title:
- CANCER RESEARCH AND CLINIC
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1006-9801.2001.01.007
- Key Word:
- p53;mdm2;免疫组织化学;骨巨细胞瘤
Abstract： 目的:探讨p53和mdm2在骨巨细胞瘤(GCT)的表达及与GCT病理分级和复发的关系.方法:应用SP免疫组织化学方法检测p53和mdm2在52例GCT(GCT按Jaffe分级:Ⅰ级15例、Ⅱ级25例、Ⅲ级12例)中的表达.结果:14例p53表达阳性,阳性率26.9%,18例mdm2表达呈阳性,阳性率34.6%.其阳性表达与病理分级均无显著性差异(P值分别为0.699;0.871).p53和mdm2在复发和无复发的病例中,阳性表达率分别为46.2%、20.5%和61.5%、25.6%.两者同时阳性表达的有7例,p53和mdm2同时过表达与GCT复发有高度显著性差异(P=0.008).结论:p53和mdm2在GCT中的表达与病理分级无关而与其复发有关.
- [1]J, Momand,G P, Zambetti,D C, Olson,etc.The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation.[J].1992,69(7).
- [2]S, Fields,S K, Jang.Presence of a potent transcription activating sequence in the p53 protein.[J].1990,249(4972).
- [3]Jiandong Chen,Jiayuh Lin,Arnold J. Levine.Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene[J].1995,1(2).
- [4]P, Rieske,J K, Bartkowiak,A M, Szadowska,etc.A comparative study of P53/MDM2 genes alterations and P53/MDM2 proteins immunoreactivity in soft-tissue sarcomas.[J].1999,18(3).
- [5]Fumiaki Masui,Shinichiro Ushigome,Katsuyuki Fujii.Giant cell tumor of bone: A clinicopathologic study of prognostic factors[J].1998,48(9).
- [6]C, Cordon-Cardo,E, Latres,M, Drobnjak,etc.Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas.[J].1994,54.
- [7]F S, Leach,T, Tokino,P, Meltzer,etc.p53 Mutation and MDM2 amplification in human soft tissue sarcomas.[J].1993,53.
- [8]Levine, A.J.,Momand, J..The p53 tumor suppressor gene.[J].1991,351(6326).
- [9]G, Reifenberger,L, Liu,K, Ichimura,etc.Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.[J].1993,53.
- [10]Gabriella Gamberi,M. Serena Benassi,Tom Böhling,etc.Prognostic relevance of C-mycgene expression in giant-cell tumor of bone[J].1998,16(1).