Influence of Electroacupuncture on Tumor Necrosis Factor-α and Vascular Endothelial Growth Factor in Rats with Experimental Arthritis
- Author:
- No author available
- Journal Title:
- Journal of Acupuncture and Tuina Science
- Issue:
- 4
- DOI:
- 10.1007/sl1726-012-0604-y
- Key Word:
- 针刺疗法;电针;关节炎,实验性;肿瘤坏死因子-α;血管内皮生长因子;大鼠;Acupuncture Therapy;Electroacupuncture;Arthritis,Experimental;Tumor Necrosis Factor-alpha;Vascular Endothelial Growth Factors;Rats
Abstract： Objective:To observe the effect of electroacupuncture (EA) on tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) in peripheral blood and joint fluid of collagen-induced arthritis (CIA) rats.Methods:After CIA rat models were successfully established,the rats were given corresponding intervention treatments.The levels of TNF-α and VEGF in peripheral blood and joint fluid were measured.Results:The levels of TNF-α and VEGF levels in peripheral blood and joint fluid of CIA rats were higher than those of normal group (P＜0.05); EA treatment significantly decreased the index levels,of significant difference compared with those before treatment (P＜0.05),as well as the model group (P＜0.05).Conclusion:EA can significantly decrease the TNF-α and VEGF levels in peripheral blood and joint fluid of CIA rats,and helps restrain further development of the disease.
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