Abstract: Based on observation and investigation of European research management,the thought of China's scientific research management and reform,this paper puts forward the idea of change,which involves reform,transformation and innovation in organization development,for Chinese research management.It expounds the theories,methods and strategies on change under the guidance of five-color theory.Further,the author analyses the issues of motivation,problems and solutions,et al.in the change of a research institute.Strategies for change are also proposed.