Abstract： Objective To provide scientific rationales through an analysis of the relationship between skin carotenoid level and metabolic syndrome related indices so as to prevent the occurrences of metabolic syndrome (MS).Methods A total of 493 cases from December 2010 to December 2011 were recruited to measure the skin carotenoid levels and various laboratory indices of metabolic syndrome.Results Along with the rising risk factors of MS,the skin carotenoid level declined.And there were significant differences between the normal group(n =103),low risk group(n =63),high risk group (n =172)and the MS group(n =155) (40 407 ± 10 961,28 396 ±8683,28 523 ± 8887,23 303 ± 8887,F =72.704,P ＜0.01).Gender and skin carotenoid level had an obvious correlation.Males were significantly lower in females (P ＜0.01).There was no correlation of age and skin carotenoid level (P ＞0.05).Conclusions Skin carotenoid level and metabolic syndrome have a negative correlation.Measurement of skin carotenoid level plays a certain role in the prevention of metabolic syndrome.