Abstract： Objective To analysis the clinical characteristics of corneal interface fluid syndrome (IFS).Methods This is a retrospective study.During Jun.2007 to Oct.2011.Eight cases (12 eyes) of IFS were diagnosed at Henan Eye Institute.The history and complete ophthalmic examination that include Slit-lamp examination,Slit-lamp photography,IOP,anterior segment OCT (AS-OCT),confocal microscopic exams were recorded.Results In total 8 cases (12 eyes),4 cases were bilateral,4 cases were unilateral.Six patients were male and 2 were female.The age of the patients ranged from 19 to 35 years.Post-lasik steroid-induced elevated IOP was 4 eyes in 2 patients.Primary open angle glaucoma was 4 eyes in 2 patients.1 patient (1 eye) was Posner-Shlossman syndrome,1 patient (1 eye) was pigmented glaucoma,1 patient (1 eye) was post-lasik traumatic iritis.1 patient (1 eye) got IFS after repeated flap reposition because of epithelium ingrowth.Slit-lamp exam indicated edematous corneal,lamellar haze,interface fluids accumulation.AS-OCT showed obvious interface dark area.Confocal microscopy exam showed edematous corneal flap,more oval and large keratocytes' nuclei but no inflammatory cells.Conclusions IFS is a rare but serious complication after LASIK.The main causes are high intraocular pressure and/or dysfunction of corneal endothelium.Careful exam by slit-lamp may help diagnosis,and further AS-OCT and/or in vivo confocal microscopy exam will confirm it.