Abstract： Objective To identify spatial distribution and risk factors among tuberculosis (TB) cases in Songjiang district,Shanghai,2006 -2009.Methods All active TB cases and all bacteriologically confirmed TB cases diagnosed during the period from 2006 to 2009 were recruited into the study.Spatial scan statistics were used to identify spatial clusters.Using logistic regression,we compared the demographic and clinical characteristics of TB cases in spatial clusters versus TB cases not in spatial clusters.Results A total of 1815 active TB cases and 730 bacteriologically confirmed TB cases were recruited during 2006 -2009.Chedun township and Xinqiao township was detected to be a spatial cluste( RR =1.38,LLR =16.78,P ＜0.01 ),which was the location of the municipal industrial zone.No spatial cluster was found during 2006 - 2007,while during 2008 - 2009 Chedun township was detected to be a spatial cluster (RR =1.70,LLR =15.06,P ＜ 0.01 ).Among resident population,the spatial cluster of TB cases was located in the southwestern part of Songjiang district,which included five townships Xinbang,Shihudang,Xiaokunshan,Maogang and Yongfeng( RR =1.49,LLR =10.52,P ＜ 0.01 ) ; while among migrant population,the spatial cluster of TB cases was located in Chedun township(RR =1.55,LLR =15.64,P ＜0.01 ).There were higher proportions of resident TB cases who were farmers (AOR =4.9,95％ CI:1.9 - 12.3 ) or had other occupations (AOR =2.6,95％ CI:1.1 - 5.9 ) in the spatial cluster.There were higher proportions of migrant TB cases who lived here for less than 5 years( ＜1 year:AOR=5.9,95％CI:1.8-19.5; 1 -5 years:AOR =3.2,95 ％ CI:1.0 - 9.9 ) or worked at other occupations ( AOR =2.8,95 ％ CI:1.5 - 5.1 ) and lower proportions of migrant TB cases who came from Eastern region (AOR =0.3,95％ CI:0.1 -0.8 ) or Middle region(AOR =0.5,95％ CI:0.3 -0.9) in the spatial cluster.Conclusion In Songjiang district there was a spatial cluster in TB cases,which was Chedun township.Local residents with TB who were farmers or had other occupations were more likely to be in the spatial cluster.Migrants with TB who lived here for less than 5 years or came from Western region were more likely to be in the spatial cluster.