Optical coherence tomography characteristics and relation with vision in polypoidal choroidal vasculopathy before and after photodynamic therapy

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Author:
ZHANG Li-juan(Weifang Medical University, Weifang 261042, China)
TAO Yuan()
WANG Yu()
()
()
Journal Title:
Chinese Journal of Ocular Fundus Diseases
Issue:
Volume 28, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1005-1015.2012.05.008
Key Word:
Choroid diseases/therapy; Tomography, optical coherence; Photochemotherapy

Abstract: Objective To observe the characteristics of optical coherence tomography (OCT)in polypoidal choroidal vasculopathy (PCV) before and after photodynamic therapy (PDT),and investigate its relationship with visual acuity.Methods Thirty-four PCV patients (40 eyes) diagnosed by fundus fluoresce angiography and indocyanine green angiography who had underwent the treatment of PDT,were enrolled in this study.The logMAR corrected visual acuity (CVA) were detected and the height and the base diameter of retinal pigment epithelium detachment (PED)and retinal detachment (RD),central subfield thickness (CST),macular volume (MV) were measured by OCT before and after treatment.Before the treatment,the mean logMAR CVA was 0.66 0.32 and visible PED and RD were seen on OCT images.The OCT characteristics and relationship with visual acuity were comparatively analyzed.Results One,three,six and 12 months after treatment,the mean logMAR CVA were 0.58 0.27,0.48 0.38,0.51 0.37 and 0.50 0.36.The differences of CVA were statistically significant between before-treatment and three,12 months after treatment(t=2.32,2.10; P<0.05),but not between before-treatment and one,six months after treatment (t=1.22,1.961 P>0.05).The differences of the height and the base diameter of PED were statistically significant between before-treatment and six,12 months after treatment (t=2.34,2.03; P<0.05),but not between before-treatment and one,three months after treatment (t =1.07,1.50; P > 0.05).The differences of the height (t=2.22,2.99,3.30,3.95) and the base diameter (t=2.55,3.33,3.11,3.92)of RD were statistically significant between before-treatment and one,three,six and 12 months after treatment (P<0.05).The differences of CST (t=2.71,3.55,3.81,3.21) and MV (t=2.10,3.30,3.62,4.18) were statistically significant between before-treatment and one,three,six and 12 months after treatment (P<0.05).CVA had negative correlation with the base diameter of PED,the height and the base diameter of RD,CST and MV (r=-0.88,-0.89,-0.92,-0.86,-0.94; P<0.05),no correlation with the height of PED (r=-0.70,P>0.05).Conclusions The height and the base diameter of PED and RD,CST,MV of PCV are decrease after PDT.There is a negative correlation between CVA and the base diameter of PED,the height and the base diameter of RD,CST and MV.

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