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The cell of origin of human retinoblastoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1015-1005.2009.06.02
- Key Word:
- 视网膜母细胞瘤/病理生理学;基因;视网膜母细胞瘤;视网膜母细胞瘤蛋白质;视锥(视网膜)/病理学;述评;Retinoblastoma/pathophysiology;Genes;retinoblastoma/physiology;Retinoblastoma protein;Cones (retina)/pathology;Editorial
Abstract： The debate on the cell of origin of human retinoblastoma lasted for more than one century.In the recent issue of "cell",David Cobrinik's group shows that L/M cone precursors are the most likely answer as they have an intrinsic circuitry,including murine double minute 2 (MDM2),N-myc,the nuclear receptors retinoid X receptor and thyroxine receptor 2,making them extremely sensitive to transformation following retinoblastoma gene inactivation.
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