You Position: Home > Paper

Damage of the retrograde axial flow of retinal ganglion cells in diabetic rats at the early stage

( views:230, downloads:17 )
Author:
No author available
Journal Title:
CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
Issue:
1
DOI:
10.3760/j.issn:1005-1015.2006.01.002
Key Word:
糖尿病/病理生理学;视网膜神经节细胞;染色与标记

Abstract: 目的观察早期糖尿病大鼠视网膜神经节细胞(RGC)逆行轴浆流速是否受损,并判断损伤细胞的类型.方法Sprague-Dawley(SD)成年雄性大鼠6只,腹腔注射链脲佐菌霉素(STZ)形成糖尿病模型,4周时行荧光金(FG)上丘定位逆行标记.分别于FG注射后12、72 h行视网膜铺片,在荧光显微镜下拍照后做尼氏染色,统计FG标记的不同大小RGC比例.另6只正常SD成年雄性大鼠作为对照.结果FG注射12 h后,实验组RGC总数与对照组无差别,但小直径RGC比例明显低于对照组;72 h后,实验组RGC数比对照组明显减少,小细胞减少尤其明显.结论糖尿病早期大鼠RGC逆行轴浆流速受到影响,小直径RGC容易受损.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn