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Analysis of risk factors of severe retinopathy of prematurity
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1005-1015.2005.05.001
- Key Word:
- 视网膜病;早产儿;危险因素;因素分析;统计学
Abstract： 目的分析严重早产儿视网膜病变(ROP)的危险因素,为合理制定ROP筛查标准提供参考依据. 方法回顾性分析2002年12月至2004年4月期间我院眼科就诊的168例孕龄<37周的早产儿临床资料.记录其性别、胎数(BC)、孕龄(GA)、出生体重(BW)、氧疗时间以及双眼充分散瞳后双目间接检眼镜检查所见的视网膜血管发育情况.按ROP国际分类法(ICROP)记录检查结果,1、2、3期为轻度ROP,阈值病变、4期和5期为严重ROP.应用多元Logistic回归分析分析ROP与性别、BC、GA、BW、氧疗时间等因素之间的关系. 结果 168例早产儿336只眼中,严重ROP 47例91只眼,分别占患儿例数和眼数的28.0%、27.1%.其中,阈值病变20只眼,占6.0%;4期病变11只眼,占3.3%.4期病变中,4A期2只眼,占0.6%;4B期9只眼,占2.7%.5期60只眼,占17.8%.各因素中,GA、BW和氧疗时间对严重ROP的发生有影响(P值分别为0.000、0.000和0.015,α=0.05),性别和BC与ROP无关(P值分别为0.640和0.084,α=0.05).亚变量统计分析显示,当GA≤30周或BW≤1 500 g或氧疗时间>4 d时早产儿患严重ROP的危险性显著增加. 结论严重ROP的发生受GA、BW和氧疗时间的影响,而与性别和BC无关.GA≤30周或BW≤1 500 g或氧疗时间>4 d的早产儿患严重ROP的危险性显著增加,建议重点对此类早产儿进行筛查.
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