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Association of human leukocyte angtigen-B51 and Behcet's disease with uveitis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1005-1015.2004.04.001
- Key Word:
- Behcet病,HLA-B51抗原;等位基因
Abstract： 目的探讨人类白细胞抗原(HLA)-B51与Behcet病葡萄膜炎间的相关性. 方法应用微量淋巴细胞毒试验,对27例Behcet病患者和30例健康人的HLA-A和HLA-B抗原进行研究.应用聚合酶链式反应-序列特异性引物(PCR-SSP)技术测定HLA-B51抗原阳性的Behcet病患者和对照组人群中的HLA-B51等位基因(HLA-B*5101-B*5107). 结果 Behcet病患者和对照组HLA-B51的阳性频率分别为63%和16.7%[χ2=12.9,P＜0.001,Pc＜0.05,相对危险度(RR)=8.5].在Behcet病患者中,葡萄膜炎的患病率为40.7%(11/27);72.7%(8/11)Behcet病葡萄膜炎中存在HLA-B51(均为HLA-B*5101).HLA-B51和HLA-B*5101与Behcet病葡萄膜炎存在弱相关性,但均未见统计学差异(分别为RR=2.07,χ2=0.759,P＞0.25;RR=2.67,χ2=1.395,P＞0.10). 结论提示HLA-B51(HLA-B*5101)是Behcet病的易感基因,并与葡萄膜炎有一定的相关性.
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