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The protection of aminoguanidine, silymarin and anisodamine on growth and cytosolic free calcium changes of retinal capillary pericytes cultured in glycation products

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
Issue:
3
DOI:
10.3760/j.issn:1005-1015.2001.03.008
Key Word:
周细胞/药物作用;钙/分析;水飞蓟素;山莨菪碱;胍类

Abstract: 目的探讨氨基胍(aminoguanidine,AG)水飞蓟素(silymarin,Sil)和山莨菪碱(anisodamine,Ani)对糖基化产物培养下视网膜微血管周细胞(pericytes,PC)的保护作用. 方法 MTT比色测定结合3H-TdR掺入和Fura-2AM,观察三种药物对早期糖基化产物(early glycation products of albumin,EGs)和糖基化终产物(advanced glycation end products of albumin AGEs)培养的PC增生、DNA合成和胞浆[Ca2+]i水平改变的影响. 结果 EGs培养下,AG组和Sil组MTT测定A值和3H-TdR掺入量均较对照组增高(P<0.01),而两组胞浆[Ca2+]i水平较对照组减低(P<0.01和0.05),两组比较差异具有显著性的意义;AGEs培养下,仅AG组MTT A值和3H-TdR掺入量较对照组增高(P<0.01),胞浆[Ca2+]i水平较对照组减低(P<0.05). 结论 AG能有效保护PC免受EGs所致的增生和抑制胞浆[Ca2+]i水平增高,并对AGEs所致的上述改变亦有一定的保护效应.Sil仅对EGs所致的PC增生抑制和胞浆[Ca2+]i水平改变有一定的保护作用;Ani对EGs和AGEs所致的PC上述改变均无明显保护作用.

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