VEGF mRNA expression in retinal neovascular tissue in rabbit eyes with retinal vein occlusion
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1005-1015.2001.01.003
- Key Word:
- 视网膜静脉闭塞;内皮,血管;内皮生长因子;视网膜新生血管化;基因表达
Abstract： Objective To evaluate the possible role of vascular endothelial growth factor (VEGF) in the pathogenesis of retinal neovascularization resulting from retinal ischemia． Methods Retinal vein occlusion of rabbits model was established with argon laser photocoagulation to retinal vein．The VEGF mRNA expression was observed in ischemic retina and retinal neovascular tissue with in situ hybridization technique． Results VEGF mRNA expression was detected in inner ischemic retina and retinal neovascular tissue that were corespondent to the distribution of retinal ischemia． The strongest VEGF mRNA expression was detected in retinal neovascular tissue． Conclusion VEGF might play an important role in the pathogenesis of vascular proliferative retinopathy．
- [1]D, Shweiki,A, Itin,D, Soffer,etc.Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.[J].1992,359(6398).
- [2]N, Ferrara,K, Houck,L, Jakeman,etc.Molecular and biological properties of the vascular endothelial growth factor family of proteins.[J].1992,13.
- [3]D R, Senger,S J, Galli,A M, Dvorak,etc.Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.[J].1983,219.
- [4]J W, Miller,A P, Adamis,D T, Shima,etc.Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model.[J].1994,145.
- [5]K H, Plate,G, Breier,H A, Weich,etc.Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.[J].1992,359.
- [6]P J, Keck,S D, Hauser,G, Krivi,etc.Vascular permeability factor, an endothelial cell mitogen related to PDGF.[J].1989,246.
- [7]Aiello Lloyd Paul.Hypoxic Regulation of Vascular Endothelial Growth Factor in Retinal Cells[J].1995.
- [8]D W, Leung,G, Cachianes,W J, Kuang,etc.Vascular endothelial growth factor is a secreted angiogenic mitogen.[J].1989,246.
- [9]V, Simorre-Pinatel,M, Guerrin,P, Chollet,etc.Vasculotropin-VEGF stimulates retinal capillary endothelial cells through an autocrine pathway.[J].1994,35.