Abstract： Objective To explore the safety and feasibility of permanent His-bundle pacing (HBP).Methods Seventeen patients[ ( 11 male,mean age(67.8±9.6)years)with a standard pacemaker(PM) indication or systolic heart failure who have frequent dependence on right ventricular pacing were enrolled between February,2011 and November,2011.A system consisting of a steerable catheter and a4.1 F screw-in lead were used for permanent HBP.Results After initial failure of HBP in the first 7 cases,HBP was successful in 9 patients.The total success rate was 52.9％ (9/17),but the success rate increased to 90％ in the later practice.In permanent HBP pacing,the acute pacing threshold was( 1.2±0.7 )V at pulse duration of O.4msec,and the sensed potentials were (3.5± 1.4) mV.The pacing threshold was ( 1.7 ± 1.3 ) V,and sensed potentials were (3.4±3.3) mV during 5 ～ 14 months follow-up,which were not significantly different compared with the measurements at implantation( P＞0.05 ).The QRS width was( 104.4±23.5 ) ms at implantation and( 108.9±23.7 ) ms at the follow-up,which were similar to the native QRS width( 107.8±27.7)ms.Among them,QRS width was reduced from 150 ms and 200 ms to 120、160 ms in two patients with systolic heart failure( one patient had depended on right ventricular pacing for half a year).In the two patients,cardiac function was improved (from NYHA Class Ⅲ to Class Ⅰ and Ⅱ ) after HBP.No major complications were observed.Conclusion Permanent HBP is feasible and safe,may be a better choice for the patients with systolic heart failure who require permanent PM with anticipated frequent ventricular pacing or who have frequent dependence on right ventricular pacing.