Abstract： Objective To evaluate the impact of different gastrectomy and reconstruction method on prognosis and quality of life in proximal gastric cancer.Methods The 265 cases of proxirnal gastric cancer received radical resection,according to gastrectomy or reconstruction method,were divided into proximal gastrectomy/gastroesophagostomy group (PG) ( n =63 ) and total gastrectomy/esophagojejunostomy group (TG) (n =202).The clinical pathologic features,prognosis,postoperative quality of life in 2 groups were compared.Results There had no significant differences in age,gender,CEA value between two groups ( all P ＞ 0.05 ).In PG and TG group,tumor size ( cm),ratio of organic invasion,lymph nodes metastasis,distal metastasis,TNM Ⅳ stage,Borrmann typing,poor or undifferentiated carcinoma was 2.9 ± 1.9 vs.4.8±2.8,9.5％ vs.32.2％,64.7％ vs.70.6％,0vs.8.4％,6.9％ vs.31.8％,44.4％ vs.69.2％,31.7％ vs.53.7％,respectively,all with significant difference ( t =- 6.260,x2 =29.473,14.559,5.665,32.483,12.588,10.954,all P ＜0.05).In PG and TG group,the ratio of D3 and D3 + resection,multi-visceral resection, complications was 0 vs. 13.8％, 9.5％ vs. 38.6％, 7.9％ vs. 1.5％ respectively,showed increasing range of resection and decreasing complications significantly in TG group(all P ＜0.05).The median survival time (months) was 62.5 vs.78.9 in TG and PG group respectively,without significant difference ( P ＞ 0.05 ).In 2 groups,the evaluation index of post-operative quality of life without significant differences (P ＞ 0.05 ).Conclusions For proximal gastric cancer,although the cases received TG with worse clinicopathological features,which prognosis was similar to that received PG.The postoperative quality of life without significant difference between the cases received gastroesophagostomy and esophagojejunostomy.