Risk factors of cerebral infarction in newborns

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Author:
HUANG Chun-ling(Department of Pediatrics,Peking University First Hospital,Beijing 100034,China)
ZHOU Cong-le(Department of Pediatrics,Peking University First Hospital,Beijing 100034,China)
TANG Ze-zhong(Department of Pediatrics,Peking University First Hospital,Beijing 100034,China)
LI Xue-ying()
WANG Hong-mei(Department of Pediatrics,Peking University First Hospital,Beijing 100034,China)
HOU Xin-lin(Department of Pediatrics,Peking University First Hospital,Beijing 100034,China)
Journal Title:
Chinese Journal of Perinatal Medicine
Issue:
Volume 15, Issue 06, 2012
DOI:
10.3760/cma.j.issn.1007-9408.2012.06.006
Key Word:
Brain infarction;Infant,newborn;Risk factors

Abstract: Objective To investigate the risk factors of cerebral infarction in newborns and to provide a theoretic basis for prevention.Methods From January 2002 to December 2010,8840 newborns were admitted into the Neonatology Department of Peking University First Hospital,among which 44 patients were diagnosed as cerebral infarction by review of brain imaging and medical records.These patients were taken as study group,and 175 patients were randomly selected as the control group matched by birthday and gestational age.Risk factors of neonatal cerebral infarction were analyzed by univariate analysis and binary Logistic regression.Results Of 27 352 infants born in Peking University First Hospital,21 infants were diagnosed as neonatal cerebral tnfarction,giving the prevalence of neonatal cerebral infarction of 7 per 10 000 live births (21/27 352).Of the 8840patients in Department of Neonatology,neonatal cerebral infarction accounts for 5.0‰ (44/8840).81.8% (36/44) of the affected babies were delivered at term.The incidence of hypoxia and polycythemia in study group were 50.0% (22/44) and 11.4% (5/44),higher than those in control group [27.4%(48/175) and 2.9%(5/175)],differences were statistical significant (x2 =8.237,OR=2.646,95%CI:1.343-5.211,P=0.004; x2 =5.838,OR=4.359,95%CI:1.203-15.796,P=0.030).Logistic regression showed that hypertensive disorder complicating pregnancy (OR=3.388,95%CI:1.174-9.778,P=0.024),polycythemia (OR=4.319,95%CI:1.136-16.427,P=0.032)and hypoxia (OR =2.860,95% CI:1.415-5.782,P =0.003) were risk factors for neonatal infarction.Further analysis suggested that the severity of hypoxia (x2 =- 3.470,P =0.001 ) and hypertensive disorder complicating pregnancy (x2=-2.074,P=0.038) had positive correlation with neonatal cerebral infarction.Conclusions Hypertensive disorder complicating pregnancy,polycythemia and hypoxia were risk factors of cerebral infarction,especially when preeclampsia and severe hypoxia occurred.

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