Relationship among potential maternal risk factors, prenatal care and characteristics of preeclampsia

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WANG Jia-lüe(Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191 , China)
YANG Zi(Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191 , China)
SHEN Jie(Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191 , China)
Journal Title:
Chinese Journal of Perinatal Medicine
Volume 15, Issue 03, 2012
Key Word:
Pre-eclampsia;Risk factors;Prenatal diagnosis;Physicians practice patterns

Abstract: Objective To investigate the relationship between potential maternal risk factors between potential maternal risk factors in different level hospitals as well as different prenatal care patterns and characteristics of preeclampsia. Methods A retrospective study of 300 preeclamptic singleton patients delivered in Peking University Third Hospital was performed.Patients were divided into three groups:regular prenatal care in tertiary hospitals (n =100),regular prenatal care in primary hospitals (n=81) and without prenatal care (n=119). The onset of preeclampsia and incidence of severe preeclampsia of different groups were analyzed. Non-parametric and Chi-square test were adopted for continuous and categorical variables respectively. Results (1) In total cases of preeclampsia subgroup (I-PE subgroup) and with chronic hypertension (CH subgroup),the diagnosis of preeclampsia was later in patient with regular prenatal care in tertiary hospital (patient-TH)[100,64 and 14 cases,37.1 (4.1),37.3 (1.7) and 36.3 (2.5) weeks respectively] than those with regular prenatal care in primary hospital (patient-PH) [81,54 and 9 cases,32.9 (6.7),33.8 (6.1)and 27.9(6.3) weeks respectively] (Z=72.29,51.30 and 14.58 respectively,P<0.05) or the patient without regular prenatal care (patient-NP) [119,85 and 19 cases,31.6(6.6),31.9(6.7) and 30.3(4.7) weeks respectively] (Z=86.69,58.83 and 11.33 respectively,P<0.05).The proportion of severe preeclampsia occurred earlier than 32 weeks [13.0% (13/100) vs 55.5% (66/119),9.4%(6/64) vs 50.6%(43/85),and 35.7%(5/14) vs 89.5%(17/19); x2=43.95,29.42 and 10.17respectively,P<0.05] or earlier than 34 weeks [17.0% (17/100) vs 65.5% (78/119),14.1%(9/64) vs 61.2%(52/85) and 42.9%(6/14) vs 94.7%(18/19); x2 =47.71,31.18 and 10.61 respectively,P<0.05] were lower in patient-TH than in patient-NP.(2) In patient-NP and patientPH,onset of preeclampsia was earlier in CH subgroup compared with I-PE subgroup (Z=26.61 and 22.82,P< 0.05). In patient-NP,the proportion of severe preeclampsia occurred earlier than 32 weeks (x2 =9.11,P<0.05) or earlier than 34 weeks (x2 =7.95,P<0.05) was higher in CH subgroup than in I-PE subgroup. Conclusions Regular prenatal care in tertiary hospital might effectively delay the onset of preeclampsia or severe preeclampsia,especially in patients with risk factors for preeclampsia. Assessment of risk factors for preeclampsia in early trimester should be strengthened and individualized prenatal care plan should be established.

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