Correlation between neonatal infectious diseases and brain injury

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Author:
YANG Xu-jin()
ZHOU Cong-le(Department of Pediatrics, Peking University First Hospital, Beijing 100034, China)
TANG Ze-zhong(Department of Pediatrics, Peking University First Hospital, Beijing 100034, China)
HOU Xin-lin(Department of Pediatrics, Peking University First Hospital, Beijing 100034, China)
WANG Hong-mei(Department of Pediatrics, Peking University First Hospital, Beijing 100034, China)
FAN Xi-yong(Department of Pediatrics, Peking University First Hospital, Beijing 100034, China)
JIANG Yi(Department of Pediatrics, Peking University First Hospital, Beijing 100034, China)
Journal Title:
Chinese Journal of Perinatal Medicine
Issue:
Volume 15, Issue 01, 2012
DOI:
10.3760/cma.j.issn.1007-9408.2012.01.006
Key Word:
Infant,newborn,diseases;Infection;Central nervous system diseases

Abstract: Objective To investigate the correlation between neonatal infectious disease and brain injury. Methods Clinical data of 1266 newborns with infectious diseases were collected from Peking University First Hospital from November 2005 to August 2010.The occurrence of brain injury was summarized.Related factors of brain injury caused by infection and the risk factors for severe brain injury were analyzed by Logistic regression model. Results Among the newborns with neonatal infectious diseases, the incidence of brain injury was 8.6% (108/1266), including 101 (8.0%)mild cases and seven (0.6%) severe cases. The incidence of brain injury for the newborns with severe infectious diseases was higher than those with mild infectious diseases [38.7%(29/75) vs 6.7%(79/1191),x2=92.787,P=0.000].The incidence of brain injury for the newborns with obvious inflammatory reaction was significantly higher than those without [(13.0%(26/200) vs 7.5% (77/1025),x2=6.544,P=0.011].Severe infection was independent risk factor for severe brain injury by Logistic regression model analysis (OR =15.750,95% CI:1.756-141.281,P=0.014). Conclusions Iniectious diseases could cause injury on central nervous system,especially when there are severe infections or inflammatory reactions. The severer the infection,the severer the brain injury,especially when complicated by some factors such as asphyxia and hypoglycemia.

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