Correlation between neonatal infectious diseases and brain injury

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YANG Xu-jin()
ZHOU Cong-le(Department of Pediatrics, Peking University First Hospital, Beijing 100034, China)
TANG Ze-zhong(Department of Pediatrics, Peking University First Hospital, Beijing 100034, China)
HOU Xin-lin(Department of Pediatrics, Peking University First Hospital, Beijing 100034, China)
WANG Hong-mei(Department of Pediatrics, Peking University First Hospital, Beijing 100034, China)
FAN Xi-yong(Department of Pediatrics, Peking University First Hospital, Beijing 100034, China)
JIANG Yi(Department of Pediatrics, Peking University First Hospital, Beijing 100034, China)
Journal Title:
Chinese Journal of Perinatal Medicine
Volume 15, Issue 01, 2012
Key Word:
Infant,newborn,diseases;Infection;Central nervous system diseases

Abstract: Objective To investigate the correlation between neonatal infectious disease and brain injury. Methods Clinical data of 1266 newborns with infectious diseases were collected from Peking University First Hospital from November 2005 to August 2010.The occurrence of brain injury was summarized.Related factors of brain injury caused by infection and the risk factors for severe brain injury were analyzed by Logistic regression model. Results Among the newborns with neonatal infectious diseases, the incidence of brain injury was 8.6% (108/1266), including 101 (8.0%)mild cases and seven (0.6%) severe cases. The incidence of brain injury for the newborns with severe infectious diseases was higher than those with mild infectious diseases [38.7%(29/75) vs 6.7%(79/1191),x2=92.787,P=0.000].The incidence of brain injury for the newborns with obvious inflammatory reaction was significantly higher than those without [(13.0%(26/200) vs 7.5% (77/1025),x2=6.544,P=0.011].Severe infection was independent risk factor for severe brain injury by Logistic regression model analysis (OR =15.750,95% CI:1.756-141.281,P=0.014). Conclusions Iniectious diseases could cause injury on central nervous system,especially when there are severe infections or inflammatory reactions. The severer the infection,the severer the brain injury,especially when complicated by some factors such as asphyxia and hypoglycemia.

  • [1]Dammann O,Leviton A. Maternal intrauterine infection,cytokines,and brain damage in the preterm newborn.Pediatr Res,1997,42:1-8.
  • [2]金汉珍,黄德珉,官希吉.实用新生儿学.2版.北京:人民卫生出版社,1997:259.
  • [3]杨锡强,易著文.儿科学.6版.北京:人民卫生出版社,2004:140.
  • [4]戈海延,王丹华.新生儿全身炎症反应综合征研究进展.中华医院感染学杂志,2008,18:1045-1047.
  • [5]中华医学会儿科学分会新生儿学组.新生儿败血症治疗方案.中华儿科杂志,2003,41:897-899.
  • [6]樊寻梅,武志远.国际儿科脓毒症定义会议介绍.中华儿科杂志,2005,43:618-620.
  • [7]周丛乐,陈惠金,虞人杰.新生儿颅脑超声诊断学.北京:北京大学医学出版社,2007:111-117.
  • [8]段恕诚,刘湘云,朱启镕.儿科感染病学.上海:上海科学技术出版社,2003:677.
  • [9]Wu YW,Colford JM.Chorioamnionitis as a risk factor for cerebral palsy:A meta-analysis. JAMA,2000,284:1417-1424.
  • [10]Resch B,Vollaard E,Maurer U,et al. Risk factors and determinants of neurodevelopmental outcome in cystic periventricular leucomalacia.Eur J Pediatr,2000,159:663-670.
  • [11]Cai ZW,Pan ZL,Pang Y,et al.Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration.Pediatr Res,2000,47:64-72.
  • [12]Gibson CS, MacLennan AH, Goldwater PN, et al.Antenatal causes of cerebral palsy: associations between inherited thrombophilias,viral and bacterial infection,and inherited susceptibility to infection. Obstet Gynecol Surv,2003,58:209-220.
  • [13]Yu HM,Yuan TM,Gu WZ,et al. Expression of glial fibrillary acidic protein in developing rat brain after intrauterine infection.Neuropathology,2004,24:136-143.
  • [14]Graham EM,Holcroft CJ,Rai KK,et al.Neonatal cerebral white matter injury in preterm infants is associated with cultrure positive infections and only rarely with metabolic acidosis.Am J Obstet Gynecol,2004,191:1305-1310.
  • [15]Fan LW,Mitchell HJ,Tien LT,et al.alpha-Phenyl-n-tertbutyl-nitrone reduces lipopolysaccharide-induced white matter injury in the neonatal rat brain.Dev Neurobiol,2008,68:365-378.
  • [16]Rohl C, Lucius R, Sievers J. The effect of activated microglia on astrogliosis parameters in astrocyte cultures.Brain Res,2007,1129:43-52.
  • [17]Fan LW,Mitchella HJ,Tien LT,et al. Interleukin-1β-induced brain injury in the neonatal rat can be ameliorated by alpha-phenyl-n-tert-butyl-nitrone. Exp Neurol,2009,220:143-153.
  • [18]刘云峰,周丛乐,郭在展,等.早产儿脑白质损伤后期脑体积变化与临床关系的研究.中华围产医学杂志,2008,11:388-392.
  • [19]Eschenbach DA.Amniotic fluid infection and cerebral palsy.Focus on the fetus.JAMA,1997,278:247-248.
  • [20]Resch B,Radinger A,Mannhalter C,et al.Interleukin-6G(--174)C polymorphism is associated with mental retardation in cystic periventricular leucomalacia in preterm infants.Arch Dis Child Fetal Neonatal Ed,2009,94:F304-F306.
  • [21]Nelson KB,Willoughby RE.Infection,inflammation and the risk of cerebral palsy.Curr Opih Neurol,2000,13:133-139.
  • [22]Hagberg H,Pecbles D,Mallard C.Models of white matter injury: comparison of infectious,hypoxic-ischemic, and excitotoxic insults.Ment Retard Dev Disabil Res Rev,2002,8:30-38.
  • [23]王颖,周丛乐,刘晓燕.新生儿大肠杆菌(K1抗原)脑膜炎所致颅内多发囊性病变.北京医科大学学报,1996,28:235.
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