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Value of amplitude-integrated EEG in predicting neurodevelopmental outcome of full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis

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Author:
No author available
Journal Title:
Chinese Journal of Perinatal Medicine
Issue:
11
DOI:
10.3760/cma.j.issn.1007-9408.2011.11.004
Key Word:
缺氧缺血性;脑;脑电描记术;婴儿;新生;预后;Meta分析;Hypoxia-ischemia,brain;Electroencephalography;Infant,newborn;Prognosis;Meta-analysis

Abstract: Objective To evaluate the value of amplitude-integrated EEG(aEEG)as a quantitative predictor of neurodevelopment outcome of full-term infants with hypoxic-ischemic encephalopathy(HIE).Method EMBASE,Ovid,PubMed,Cochrane Library,Springer Database,CNKI,CSJD and Wanfang Database were searched from when the database was founded to June 30,2010 for studies about aEEG as a predictor of neurodevelopment outcome in full-term infants with HIE.Characteristic information of each articles was extracted and QUADAS items were used to evaluate the qualities of included studies.Meta-disc software 1.4 was used to perform the metaanalysis.All included studies were combined with weighted quantity; sensitivity,specificity,positive likelihood ratio,negative likelihood ratio and their 95 % CI were calculated.Results Eleven studies were eligible for the primary meta-analysis and totally 717 subjects were included.There was an overall sensitivity of 86%(95% CI:81%-89%),specificity of 90%(95% CI:86%-93%),positive likelihood ratio of 7.70(95% CI:5.69-10.43),negative likelihood ratio of 0.17(95% CI:0.13-0.22)and the area under the curve(AUC)of summary receiver operating characteristic curve was 0.95 for aEEG tracings to accurately predict poor outcome of HIE in full term neonates.Conclusion aEEG is a valuable bedside tool for predicting long-term neurodevelopment outcome in term infants with HIE.

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