Prospective study of perinatal infection of cytomegalovirus in infants

( views:, downloads: )
Collaborative Team for the Study of Maternal and Infantile Cytomegalovirus Infection in Beijing()
Journal Title:
Volume 13, Issue 02, 2010
Key Word:
Cytomegalovirus infections;Prospective studies;Infant,newborn

Abstract: Objective To determine the associated factors of perinatal cytomegalovirus (CMV) infection and the impact on infantile health. Methods A prospective multieenter cohort study was conducted.The urine CMV DNA in infants without congenital CMV infection were measured with nested-polymerase chain reaction at the age of 12 weeks.According to the results of nested-polymerase chain reaction.the infants were divided into perinatal CMV infection group and non-perinatal CMV infection group.Their motor and mental development in neonatal period and 12 months old were measured and analyzed.The risk factors of perinatal CMV infection were analyzed with multivariate Logistic regression analysis. Results Among 518 in/ants,105 were positive for CMV DNA in urine samples.the rest were negative.The percentage of perinatal CMV infection was 20.27%.Logistic regression analysis showed that the maternal gynecologic history was the independent risk factor(OR =2.275,95%CJ:1.137-4.551,P=0.020),while non-breast feeding(breast and bottle feeding:OR =0.392,95%CI:0.185-0.830,exclusive bottle feeding:OR=0.101,95%CI:0.013-0.769),and per-capita 1iving space(OR=0.948,95%CI:0.917-0.980)were protective factors of CMV infection. Conclusions Breast feeding is the predominant factor for perinatal CMV infection.Perinatal CMV infection has no short-term influence on term or near-term neonatal health.

  • [1]朱汝南,钱渊,赵林清,等.聚合酶链反应技术在无菌性脑膜炎和脑炎病原诊断中的应用探讨.中国实用儿科杂志,2003,18;605-608.
  • [2]Brytting M,Sundqvist VA,Stalhandske P,et al.Cytomega-lovirus DNA detection of an immediate early protein gene with nested primer oligonucleotides.J Virol Methods,1991,32;127-138.
  • [3]中华医学会儿科学分会感染消化学组.巨细胞病毒感染诊断方案.中华儿科杂志,1999,37,441.
  • [4]方峰,董永绥,魏晴,等.巨细胞病毒感染的母婴传播研究.同济医科大学学报,1995-24;474.
  • [5]Meier J,Lienicke U,Tschirch E,et al.Human cytomegalo-virus reactivation during lactation and mother-to-child trans-misfion in preterminfants.J Clin Microbiot,2005,43:1318-1324.
  • [6]Vollmer B,Seibold-weiger K,Sehmitz-Salue C,et al.Post-natally acquired cytomegalovirus infection via breast milk,effects on hearing and development in preterm infants.Pediatr Infect Dis J,2004,23:322-327.
  • [7]Freij BJ,Sever J L.Cytomegalovirus infections//MacDonald MG,Seshia MMK,Mullett MD.Avery's neonatology pathophysiology and management of the newborn.6th ed.Philadelphial Lippincott Williams & Wilkins,2005:1291-1296.
  • [8]Alford CA,Stagno S,Pass RF,et al.Congenital and perinatal cytomegalovirus inlections.Rev Infect Dis,1990,12(Suppl 7):S745-S753.
  • [9]Schldss MR.Role of breast milk in acquisition of cytomegalovirus infection:recent advances.Curt Opin Pediatr,2006,18;48-52.
  • [10]Yasuda A,Kimura H,Hayakawa M,et al.Evaluation of cytomegalovirus infections transmitted via breast milk in preterm infants with a real-time polymerase chain reaction assay.PediatricS,2003,111;1333-1336.
  • [11]Neuberger P,Hamprecht K,Vochem M,et al.Case-control study of symptoms and neonatal outcome of human milk-transmitted cytomegalovirus infection in premature infants.J Pediatr,2006,1481326-331.
  • [12]Fowler KB,Pass RF.Risk factors for congenital cytomegalo-virus infection in the offspring of young women:exposure to young children and recent onset of sexual activity.Pediatrics,2006,118:e286-e292.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615