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Expression and significance of leptin in placenta and serum in preeclampsia

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF PERINATAL MEDICINE
Issue:
5
DOI:
10.3760/cma.j.issn.1007-9408.2008.05.009
Key Word:
瘦素;子癎前期;Leptin;Preeclampsia

Abstract: Objective To investigate the expression and alteration of leptin in placenta and serum in preeclampsia and its relationship with the disease. Methods Immunohistochemistry(SP) was used to determine the distribution and intensity of leptin staining in the placenta of 45 cases of preeclampsia(28 severe and 17 mild) and 30 cases of normal gravidas(contr01 group).Antepartum leptin level was examined using enzyme-linked immunosorbent assay method. Results (1)Leptin expression was located in the endochylema of the syncytiotrophoblast in both groups.Positive linear correlation existed between the leptin level and the severity of preeelampsia,expressed as darker staining with aggravating disease condition.(2)The serum leptin levels in all preeclampsia,mild and severe preeclampsia and normal group were(10.41±4.78)ng/ml,(6.33±1.87)ng/ml,(12.88±4.27)ng/ml and(5.73±2.19)ng/ml,respectively.Significant differences were found between preeclampsia women and normal group,mild and severe group,and severe and normal group(P<0.01).No significant difference was found when comparing mild and normal group(P>0.05).Positive linear correlation existed between the leptin expression and the severity of preeclampsia.(3)Serum leptin level had a positive correlation with systolic pressure,diastolic pressure,and mean arterial pressure(r=0.602,0.566 and 0.585,P<0.05),while no significant correlation was found between leptin level and patients'BMI(P>0.05).Conclusion Increased level of leptin in placenta and serum in preeclampsia may be involved in the occurrence and the development of the disease.

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