Comparison of maternal interleukin-1β levels in gingival cervical fluid and Serum in women with preterm

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WU Min(The Affiliated Shenzhen Maternity and Child Healthcare Hospital of the South Medical University,Shenzhen 518048,China)
LIU Shou-tao(The Affiliated Shenzhen Maternity and Child Healthcare Hospital of the South Medical University,Shenzhen 518048,China)
CHEN Shao-wu(The Affiliated Shenzhen Maternity and Child Healthcare Hospital of the South Medical University,Shenzhen 518048,China)
Journal Title:
Volume 11, Issue 03, 2008
Key Word:
Premature birth;Gingival cervicular fluid;Serum;Interleukin-1

Abstract: Objective To investigate the association of periodontal diseases in pregnancy with preterm labor by comparing maternal interleukin-1β(IL-1β)levels in gingival cervical fluid(GCF)and serum in preterm labor and full-term pregnancies. Methods Twenty-eight women with preterm labor and 22 women with full-term birth were chosen.GCF samples were collected from all individuals and serum samples were collected from 12 of them,respectively.Interleukin-1β levels were measured by enzyme-linked immunoabsorbent assay(ELISA). Results IL-1β levels in GCF were significantly higher in preterm mothers than those in the full-term group[(66.66 4.50)pg/ml vs(38.77 8.14)pg/ml,P<0.01].And no significant difference was found between the two groups on the serum levels of IL-1β[(3.26 0.25)pg/ml vs(2.78 0.13)pg/ml,P>0.05].Negative correlations were observed between IL-1β levels in GCF and the gcstational age at the onset of preterm labor (r=-0.555,P<0.05). Conclusions Periodontal infections may associated with preterm labor.

  • [1]Offenbacher S,Katz V,Fertik G,et al.Periodontal infection as a risk factor for preterm low-birth-weight.J Periodontol,1996,67(10 Suppl):1103-1113.
  • [2]Jarjoura K,Devine PC,Perez-delhoy A,et al.Markers of periodontal infection and preterm birth.Am J Ohstet Gynecol,2005,192:513-519.
  • [3]Jeffcoat MK,Hauth JC,Geurs NC,et al.Periodontal disease and pre-term birth:results of a pilot intervention study.J Periodontol,2003,74:1214-1218.
  • [4]Davenport ES,Williams CE,Sterne JA,et al.Maternal periodontal disease and preterm low birthweight:case-control study.J Dent Res,2002,81:313-318.
  • [5]Moore S,Randhawa M,Ide M.A case-control study to investigate an association between adverse pregnancy outcome and periodontal disease.J Clin Periodontal,2005,32:1-5.
  • [6]李晓军,孔经贾,陈晖,等.先兆早产孕妇牙周状况与妊娠结局的关系.中华口腔医学杂志,2006,41:599-601.
  • [7]乐杰.妇产科学.6版.北京:人民卫生出版社,2005:93.
  • [8]Bassani DG,Da Silva CM,Oppermann RV.Validity of community periodontal intex of treatment needs'(CPITN)for population periodontitis screening.Cad Saude Publica,2006,22:277-283.
  • [9]吴亚菲,谭春,张静仪,等.龈沟液中1L-1夂虸L-1崴郊捌溆胙乐芰俅仓副甑墓叵?四川大学学报(医学版),2004,35:683-686.
  • [10]Baud O,Emilie D,Pelletier,et al.Amniotic fluid concentrations of interleukin-1 beta,interleukin-6 and TNF-?in chorioamnionitis before 32 weeks of gestation:histological associations and neonatal outcome.BJOG,1999,106:72-77.
  • [11]Tatamani T,Tsunoda H,Iwasaki H,et al.Existence of both IL-1 alpha and beta in normal human amniotic fluid:unique high molecular weight form of IL-1 beta.Immunology,1988,65:337-342.
  • [12]Flynn A,Finke JH,Hilfiker ML,et al.Placental mononuclear phagocytes as a source of interleukin-1.Science,1982,218:475-477.
  • [13]Opsjon SL,Wathen NC,Tingulstad S,et al.Tumor necrosis factor,interleukin-1,and interleukin-6 in normal human pregnancy.Am J Obstet Gynecol,1993,169(2Pt1):397-404.
  • [14]Offenbacher S,Jared HL,0'Reilly PG,et al.Potential pathogenic mechanisms of periodontitis associated pregnancy complications.Ann Periodontol,1998,3:233-250.
  • [15]Carta G,Persia G,Falciglia K,et al.Periodontal disease and poor obstetrical outcome.Clin Exp Obstet Gynecol,2004,31:47-49.
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