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Different pregnancy outcomes show the heterogeneity in women with gestational impaired glucose tolerance
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1007-9408.2007.04.009
- Key Word:
- 糖尿病,妊娠;妊娠结局;预后
Abstract： 目的 从妊娠预后角度,探讨不同时点妊娠期糖耐量受损(gestational impaired glucose tolerance,GIGT)之间是否存在异质性.方法 选取2000年至2006年在上海交通大学附属第一医院行50 g糖筛查异常的孕妇1145例为研究对象,进行75 g葡萄糖耐量试验,同时进行胰岛素释放试验,计算血糖曲线下面积及胰岛素敏感性指数,并随访至妊娠终止.比较1145例孕妇中,OGTT1 h异常(68例)及2 h/3 h异常(40例)两种糖耐量受损患者之间预后的差异,并与妊娠期糖尿病(gestational diabetes mellitus,GDM)患者(382例)及糖代谢正常(normal glucose tolerance,NGT)孕妇(655例)进行比较.结果 1 h GIGT孕妇巨大儿和新生儿低血糖发生率(10.29%和13.24%)与2 h/3 h糖耐量受损孕妇(5.00%和5.00%)及NGT患者(4.42%和4.73%)比较明显升高(P＜0.01),而2 h/3 h糖耐量受损孕妇巨大儿及新生儿低血糖发生率显著低于GDM组(11.26%和17.80%)(P＜0.01).结论 妊娠期糖耐量受损孕妇存在异质性.
- [1]李萍,杨慧霞,董悦.妊娠期糖耐量减低的处理与新生儿结局的关系[J].1999,(8).
- [2]Kirwan JP,Kalhan SC,Huston-Presley L,etc.Clinically useful estimates of insulin sensitivity during pregnancy: validation studies in women with normal glucose tolerance and gestational diabetes mellitus.[J].2001,24(9).
- [3]徐先明,乔敏,江明礼.胰岛素抵抗与妊娠高血压综合征发病的关系[J].2000,(10).
- [4]M, Matsuda,R A, DeFronzo.Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.[J].1999,22.
- [5]A. Vambergue,M. C. Nuttens,O. Verier-Mine,etc.Is mild gestational hyperglycaemia associated with maternal and neonatal complications? The Diagest Study[J].2000,17(3).
- [6]Yang, Xilin,Hsu-Hage, Bridget,Dong, Ling,etc.Intensive Diabetes Management May Improve Pregnancy.[J].2003,26(1).
- [7]Zhang C,Zhang C,Yang X,etc.Women with impaired glucose tolerance during pregnancy have significantly poor pregnancy outcomes.[J].2002,25(9).
- [8]Connelly PW,Sermer M,Hanley AJ,etc.Impaired glucose tolerance of pregnancy is a heterogeneous metabolic disorder as defined by the glycemic response to the oral glucose tolerance test.[J].2006,29(1).
- [9]B M, Casey,M J, Lucas,D D, Mcintire,etc.Pregnancy outcomes in women with gestational diabetes compared with the general obstetric population.[J].1997,90(6).