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Changes of plasma oxidized low density lipoprotein and soluble intercellular adhesion molecule-1 in women with preeclampsia
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1007-9408.2007.02.001
- Key Word:
- 子(癎)前期;脂蛋白类,LDL;胞间黏附分子1
Abstract： 目的 探讨子(癎)前期(preeclampsia, PE)患者血浆中氧化低密度脂蛋白(oxidized low density lipoprotein, oxLDL)和可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1, sICAM-1)水平的变化及其意义.方法 采用酶联免疫吸附法(enzyme-linked immunosorbent assay, ELISA),检测50例PE患者[PE组,其中子(癎)前期轻度(mild preeclampsea,MPE)及子(癎)前期重度(severe preeclampsia, SPE)各25例]及25例同期正常孕妇(对照组)血浆中oxLDL和sICAM-1的水平变化.结果 PE患者血浆中oxLDL和sICAM-1水平[分别为(30.56±10.29)μg/dl和(703.25±184.21)μg/L]均显著高于对照组[分别为(21.48±10.41)μg/dl和(258.07±67.45)μg/L, P均＜0.01]. PE组中,SPE组oxLDL和sICAM-1的水平[分别为(33.74±9.57)μg/dl和(820.02±173.47)μg/L] 均显著高于MPE组[分别为(27.39±10.18)μg/dl和(586.48±103.85)μg/L, P＜0.05和＜0.01].PE组血浆oxLDL与sICAM-1的水平呈显著正相关(r=0.6175,P＜0.01).结论 PE的发病与血清中oxLDL和sICAM-1的水平异常有密切关系.
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