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Comparison of uterine NK cell phenotypes and T lymphocytes between uterine basal decidua and peripheral blood in human term pregnancy

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF PERINATAL MEDICINE
Issue:
5
DOI:
10.3760/cma.j.issn.1007-9408.2006.05.007
Key Word:
妊娠;免疫耐受;杀伤细胞,天然;T淋巴细胞

Abstract: 目的 探讨足月妊娠母胎界面及系统免疫中NK、T细胞的免疫状态变化及其相互关系.方法 对10例正常足月妊娠妇女,剖宫产同时采集子宫底蜕膜、外周静脉血,通过流式细胞技术,检测其NK细胞亚群、NK细胞表面受体CD69、CD94及Th1/Th2免疫状态. 结果底蜕膜和外周血中各指标结果为:CD56brightCD16-含量:(18.72±17.73)%和(0.28±0.18)%;CD56+CD69+亚群:(34.98±19.79)%和(3.33±1.27)%;CD56brightCD94+含量:(15.94±13.19)%和(1.17±1.19)%;CD56+CD16-/CD56+CD16+比值:(2.30±2.25)和(0.34±0.28);CD56+CD69+/CD56+CD94+比值:(1.21±0.66)和(0.28±0.12),差异均有统计学意义(P<0.01);底蜕膜中Th1、Th2、Tc1细胞含量及Th1/Th2、Tc1/Tc2比值与外周血均无显著性差异(P>0.05);子宫底蜕膜中自然杀伤细胞(uterine natural killer cell,uNK细胞)亚群,uNK细胞表面受体CD69、CD94,Th1/Th2免疫状态与外周血均无相关性(P>0.05).结论与维持妊娠免疫耐受关系极大的uNK细胞,在足月妊娠底蜕膜中保持相对的活化状态,同时uNK、T细胞的变化独立于外周血中的免疫状态.

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