You Position: Home > Paper
Interphase FISH of amniocytes in the third trimester
( views:271, downloads:24 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1007-9408.2006.01.006
- Key Word:
- 羊膜腔穿刺术;妊娠末期;原位杂交,荧光
Abstract： 目的前瞻性研究孕28周以后羊水细胞的荧光原位杂交.方法采用盲法,对孕28周后需进行产前诊断的32例孕妇在取脐带血的同时抽吸5 ml羊水进行荧光原位杂交.结果32例孕妇发现染色体数目异常6例(18三体3例,21三体2例,47XYY 1例).且羊水细胞荧光原位杂交结果与脐带血染色体核型分析的结果一致,符合率达100%.结论孕28周后羊水细胞荧光原位杂交,对常见的染色体数目异常诊断准确性高,有一定的临床推广价值.
- [1]Eiben B.,Trawicki W.,Hammans W.,etc.Rapid Prenatal Diagnosis of Aneuploidies in Uncultured Amniocytes by Fluorescence in situ Hybridization[J].1999,14(4).
- [2]F, Orlandi,G, Damiani,C, Jakil,etc.The risks of early cordocentesis (12-21 weeks): analysis of 500 procedures.[J].1990,10.
- [3]Law ME,Jalal SM,Carlson RO,etc.Prenatal detection of aneuploidy by directly labeled multicolored probes and interphase fluorescence in situ hybridization.[J].1998,73(2).
- [4]Narula Komal,Barth WilliamH Jr,Gordon MichaelC,etc.Complications of third-trimester amniocentesis using continuous ultrasound guidance.[J].2002,99(2).
- [5]Lowther GW,Connor JM,Imrie SJ,etc.Two years' prospective experience using fluorescence in situ hybridization on uncultured amniotic fluid cells for rapid prenatal diagnosis of common chromosomal aneuploidies.[J].1999,19(6).
- [6]Mary E. D'Alton,Fergal D. Malone,David Chelmow,etc.Defining the role of fluorescence in situ hybridization on uncultured amniocytes for prenatal diagnosis of aneuploidies[J].1997,176(4).