Association between small heterodimer partner gene and high birth weight infants
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1007-9408.2005.05.015
- Key Word:
- 微小异源二聚体伙伴基因;出生体重;胚胎和胎儿发育;多态现象(遗传学)
Abstract： 目的评价微小异源二聚体伙伴基因(small heterodimer partner gene, SHP)基因与新生儿出生体重的关系. 方法应用队列研究的方法,收集191例无妊娠合并症及并发症的母血及新生儿脐血标本,利用PCR-RFLP的方法研究SHP基因的单核苷酸多态性,(single nucleotide polymorphism, SNP)位点rs7504的基因多态性. 结果 (1)随出生体重的增加新生儿携带C等位基因和TC+CC基因型频率增加,且有统计学差异(P=0.004;P=0.005);孕妇C等位基因和TC+CC基因型频率亦随新生儿出生体重增加而增加,有统计学差异(P=0.013,P=0.013).(2)此位点携带C等位基因者新生儿体重增加,携带TC+CC基因型的新生儿比携带TT基因型的新生儿体重平均增加246.3 g [(3658.7±400.9)g和(3412.4±444.4)g, P=0.005)].同时孕妇携带C等位基因者其分娩新生儿体重比不携带C等位基因孕妇分娩的新生儿体重平均增加210.3 g [(3418.6±449.0)g和(3628.9±405.5)g,P=0.011)].(3)比较脐血TC+CC基因型与TT基因型的临床参数,发现SHP基因与血糖和胰岛素不相关;与母亲的体重、孕前BMI、父亲的身高、体重相关.孕妇携带TC+CC基因型者体重和孕前BMI略有增加,但无统计学差异;且与血糖和胰岛素水平无明显相关.(4)多因素分析结果表明孕妇身高、孕期增重、孕前BMI、分娩孕周、脐血胰岛素、母血胰岛素水平均与新生儿体重相关,调整以上因素之后,脐血SHP基因仍与新生儿体重显著相关(P=0.0354),母血SHP基因与新生儿体重无明显相关(P>0.05). 结论 SHP基因与新生儿出生体重相关,在胎儿宫内发育中起一定的作用.
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