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Expression of placental vascular growth factor in pregnancy-induced hypertension

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF PERINATAL MEDICINE

Issue:: 2

DOI:: 10.3760/cma.j.issn.1007-9408.2005.02.001

Key Word:: 妊娠并发症,心血管;高血压;血管内皮生长因子A;成纤维细胞生长因子2;胎盘

Abstract：目的通过比较正常孕妇与妊娠高血压综合征(妊高征)患者胎盘分泌的血管生长因子,包括血管内皮生长因子、碱性成纤维细胞生长因子及血小板来源生长因子的表达变化,探讨血管生长因子在妊高征的表达及意义.方法采集正常孕妇(15例)及妊高征患者(19例)的胎盘组织,采用免疫组织化学PAP法结合计算机显微图像分析软件,检测胎盘血管生长因子的表达.结果妊高征组中,中、重度妊高征患者胎盘的血管内皮生长因子阳性反应平均灰度值为61.6±3.7,明显低于正常妊娠组的71.1±5.8和轻度妊高征的70.9±8.9,差异有统计学意义(P＜0.01);碱性成纤维细胞生长因子阳性反应平均灰度值为60.9±8.8,较正常妊娠组的79.7±7.6和轻度妊高征的78.4±10.4明显下降,差异有统计学意义(P＜0.01);血小板来源生长因子阳性反应平均灰度值为37.5±5.6,较正常妊娠组的22.1±3.1和轻度妊高征的21.8±4.3明显增加,差异亦有统计学意义(P＜0.01).结论胎盘血管生长因子表达异常,可能导致胎盘血管面积下降,胎盘血管壁张力增高、痉挛,从而影响胎盘的血液供应,导致妊高征的一系列病理生理改变;表达异常的程度与妊高征病情轻重有关.

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