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Expression of hepatocyte growth factor in placenta in PIH
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1007-9408.2004.02.001
- Key Word:
- 肝细胞生长因子;妊娠并发症,心血管;高血压;胎盘;新生血管化,生理性
Abstract： 目的探讨肝细胞生长因子(hepatocyte growth factor,HGF)在正常妊娠妇女胎盘和妊高征患者胎盘组织中的表达及对妊高征胎盘绒毛血管发生的影响. 方法不同程度妊高征晚孕和正常妊娠晚孕孕妇共78例,采用免疫组织化学SP法检测胎盘组织HGF的表达强度,同时作HE染色,选取5个高倍视野,计数绒毛血管数. 结果 HGF主要表达于绒毛间质细胞胞浆,蜕膜细胞有少量表达.重度妊高征患者胎盘绒毛间质细胞HGF表达强度(+++)为1例,显著低于正常晚孕组的表达强度(+++)为4例(H=7.395,P=0.003),而轻度及中度妊高征组HGF表达强度(+++)均为2例与正常晚孕组比较,差异无显著性(H=0.869,P=0.351,H=0.017,P=0.896).不同程度妊高征胎盘绒毛血管密度均较正常孕妇减少,重度妊高征组绒毛血管密度为(57.51±15.49)个/400×与正常晚孕组(67.91±16.90)个/400×相比,差异有显著性(F=10.676,P=0.008).相关分析显示,胎盘间质细胞HGF表达强度与绒毛血管密度呈正相关(r=2.246,P=0.030). 结论 HGF在胎盘中主要由绒毛间质细胞分泌,妊高征患者HGF分泌减少可能是引起胎盘血管网减少的原因之一.
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