Serum Levels of Soluble Intercellular Adhesion Molecule-1(sICAM-1) in Women with Pregnancy-induced Hypertension (PIH) and Its Roles in the Pathogenesis of PIH
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1007-9408.2003.02.002
- Key Word:
- 妊娠并发症,心血管;高血压;细胞间粘附分子1;白细胞介素1;肿瘤坏死因子
Abstract： 目的探讨可溶性细胞间粘附分子1(soluble intercellular adhesion molecule-1,sICAM-1)在妊娠高血压综合征(简称妊高征)发病中的作用. 方法应用酶联免疫吸附法(ELISA)测定65例妊高征患者(妊高征组,包括轻度15例,中度24例,重度26例)及25例同期正常妊娠孕妇(对照组)外周血清中sICAM-1的含量;应用化学发光酶联免疫分析法测定两组孕妇血清中白细胞介素1(interleukin-1, LI-1β)及肿瘤坏死因子(tumor necrosing factor alpha, TNF-α)含量;并记录新生儿体重及妊娠结局. 结果轻、中、重度妊高征组母血清中sICAM-1的含量[(368.56±62.81)μg/L、(606.63±105.04)μg/L、(859.36±200.92)μg/L]均显著高于对照组[(236.69±96.33)μg/L](P<0.05,P<0.01,P<0.01),中、重度妊高征组母血清中IL-1β及TNF-α的含量均显著高于对照组(P<0.05,P<0.01);中、重度妊高征组sICAM-1的水平与相应IL-1β及TNF-α的水平呈显著的正相关(r=0.697,P<0.01;r=0.746,P<0.01).重度妊高征组伴胎儿生长受限(fetal growth restriction, FGR)者血中sICAM-1含量显著高于同组其他孕妇之含量(P<0.05).妊高征组中,中度组sICAM-1含量显著高于轻度组(P<0.01),重度组又显著高于轻度组及中度组(P<0.01,P<0.01). 结论妊高征患者外周血中sICAM-1含量显著升高,重度及合并胎儿生长受限者其值升高更为明显,提示妊高征患者体内存在内皮细胞损伤或功能失调的病理过程.sICAM-1可作为妊高征患者内皮细胞损伤的指标加以监测,帮助判断妊高征的严重程度及估计母儿预后.
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