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The Relationship between Gene Polymorphism of Angiotensin Ⅱ Type 1 Receptor and Plasma Endothelin in Pregnancy-induced Hypertension
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1007-9408.2003.01.004
- Key Word:
- 受体,血管紧张素;多态现象(遗传学);内皮缩血管肽类;妊娠并发症,心血管;高血压
Abstract： 目的研究血管紧张素Ⅱ-1型受体(Angiotensin Ⅱ Type 1 Receptor, AT1R )基因1166位点多态性及血浆内皮素(Endothelin,ET)在妊娠高血压综合征(简称妊高征)发病中的相关性 . 方法应用聚合酶链反应、限制性内切酶酶解及电泳分型的方法对AT 1R基因1166位点的多态性进行分析,放射免疫法测定两组血浆ET值. 结果 (1)妊高征组AT1R基因1166位点变异体(AC、CC)频率明显高于正常妊娠组(χ 2=11.06,P<0.01),两组间C等位基因频率比较差异也非常显著 (χ2=9.73,P<0. 01).(2)妊娠妇女AT1R基因1166位点变异型与野生型发生妊高征的比值比(OR)为4.95, 95%可信限为1.93～12.72.(3)随着妊高征病情加重,AT1R基因变异频率无增高趋势.(4) 妊高征组与正常妊娠组间ET值比较差异非常显著,(t=5.58,P<0.01).(5)正常妊娠组中不同基因型之间ET水平比较差异无显著性(t=0.83,P>0.05);妊高征组变异型ET 水平较野生型增高(t=2.53,P<0.05). 结论 (1)AT1R基因1166 位点的变异与妊高征发病有关,C等位基因可能是妊高征的易感基因.(2)妊高征患者AT1R 基因A 1166 C变异与血浆ET的升高有一定相关性.
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