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Role of Soluble Intracellular Adhesion Molecule-1, Co rticotropin-releasing Hormone and Interleukin-6 in the Pathogenesis of Pregnan cy-induced Hypertension
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1007-9408.2002.01.004
- Key Word:
- 妊娠并发症,心血管;高血压;促肾上腺皮质素释放激素;胞间粘附分子1;白细胞介素6
Abstract： 目的研究可溶性细胞粘附分子1(s oluble intracellular adhesion molecule-1,sICAM-1)、促肾上腺皮质激素释放激素(c ortictropin-releasing hormone, CRH)及白细胞介素6(interleukin-6,IL-6)在妊娠高血压综合征(妊高征)发病中的作用. 方法测定81例妊娠26～37周孕妇血浆sICAM-1、CRH、IL-6水平,其中23例,为正常孕妇(正常妊娠组);58例为妊高征孕妇(妊高征组):包括轻度21例、中度19例、重度18例.用酶联免疫法测定sICAM-1及IL-6,用放射免疫法测定CRH. 结果中、重度妊高征患者的血sICAM-1、CRH 、IL-6水平均显著高于正常对照组(P<0.05),轻度妊高征患者与正常组相比虽无统计学差异但有升高的趋势.IL-6水平与CRH呈正相关(r=0.51,P<0.05). 结论妊高征患者血sICAM-1升高表明内皮细胞损伤在妊高征的发病中起重要作用.CRH分泌的异常增加可能与内皮细胞的损伤有关,该作用可能是通过促进IL-6的分泌实现的.
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