Expression of Heparin-binding Epidermal Growth Factor(HB-EGF) in Human Villi and Decidua in Early Pregnancy
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1007-9408.2001.01.004
- Key Word:
- 表皮生长因子-尿抑胃素;绒毛膜绒毛;蜕膜;免疫组织化学;妊娠初期
Abstract： Objective To investigate the expression and localization ofHB-EGF in human first trimester villi and decidua, and its significance in embryonic implantation and placental growth and development. Methods By immunohistochemical method the expression of HB-EGF was observed in 18 cases of human first trimester villi and decidua. Results HB-EGF can be detected in all villi and decidua of the early pregnant tissue, HB-EGF located on cell membrane and cytoplasm in trophoblast cells and glandular and stromal cells in decidua. The expression of HB-EGF in trophoblast cells was higher than that in decidua. Conclusions The expression of HB-EGF in human villi and decidua may contribute to embryonic implantation and growth, and to maintain the placental functions.
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