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Clinical Study of Preventing HBV Intrauterine Infection by Active and Passive Immunization of Pregnant Women
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1007-9408.2000.01.001
- Key Word:
- 肝炎,乙型;疾病传播,垂直;免疫球蛋白类,静脉内;肝炎疫苗,乙型
Abstract： 目的 探讨孕妇主动与被动联合免疫预防乙型肝炎病毒(HBV)宫内感染的作用和机理.方法 将53例HBsAg(+)孕妇分成两组,预防组30例,自孕20周起多次注射乙肝疫苗(HBVac)和乙肝免疫球蛋白(HBIG);对照组23例,不用HBVac和HBIG.母儿血清HBsAg、HBeAg和抗-HBs用固相放免法检测,HBV-DNA用套式PCR检测.结果 预防组新生儿血清HBsAg和HBV-DNA检出率明显低于对照组(3.3%与26.1%, 10%与34.8%) P均＜0.05;预防组新生儿抗-HBs阳性率显著高于对照组(33.3%与8.7%) P＜0.05.结论 孕妇于孕期通过HBIG和HBVac免疫,可有效预防HBV宫内感染,其机理可能为胎儿获得被动免疫.
- [1]徐志一,段恕诚,陈如钧,等.乙型肝炎疫苗阻断乙型肝炎病毒母婴传播的初步报告[J].1984,(3).
- [2]曹文娥,穆文广,马秀文,等.HBV围产期感染和宫内阻断的临床研究[J].1992,(1).
- [3]李祥芳,吴萍.孕妇免疫预防新生儿破伤风[J].1993,028 (2).
- [4]胡桂英,谭文华,马金赏,等.妊娠后期接种乙肝疫苗免疫效果的观察[J].1995,(6).
- [5]E.A. Ayoola,A.O.K. Johnson.Hepatitis B vaccine in pregnancy: Immunogenicity, safety and transfer of antibodies to infants[J].1987,25(4).
- [6]Badur S.,Lazizi Y.,Ugurlu M.,etc.Transplacental Passage of Hepatitis B Virus DNA from Hepatitis B e Antigen-Negative Mothers and Delayed Immune Response in Newborns[J].1994.
- [7]王晓霞,李香莲,张丽娟,等.孕妇破伤风类毒素免疫效果监测[J].1988,(3).
- [8]Zhang SL,Han XB,Yue YF.Relationship between HBV viremia level of pregnant women and intrauterine infection: neated PCR for detection of HBV DNA[J].1998,(1).