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PGE2 and Feto-Placental Circulation
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1007-9408.1999.04.004
- Key Word:
- 地诺前列酮;胎盘;钙;血液速度
Abstract： 目的 探讨前列腺素E2(PGE2 )对正常妊娠及妊高征孕妇胎儿胎盘循环的调节作用.方法 在50例足月正常孕妇(对照组)及37例妊高征合并IUGR孕妇(妊高征组)中,利用共焦点激光扫描显微镜测定了PGE2 对人脐静脉内皮细胞(HUVEC)内游离钙离子(Ca2+)i动态变化的影响,同时用放免法测定了其脐静脉血中PGE2 浓度.结果 PGE2使两组HUVEC中(Ca2+)i上升, 脐血中PGE2 值在妊高征组为5.4±0.6 pg/ml与对照组的15.3±1.2 pg/ml相比,显示有意义的低值(P＜ 0.05).结论 PGE2可能为胎儿胎盘循环的血管扩张因子;妊高征组脐血中PGE2 浓度降低使胎儿胎盘血流阻力增加可能影响胎儿生长发育.
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