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The Serum Level of Nitric Oxide, Superoxidate Dismutase and Lipid Peroxidate in Patients with Pregnancy-induced Hypertension
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1007-9408.1999.03.005
- Key Word:
- 妊娠并发症,心血管;高血压,一氧化氮;超氧化物歧化酶;过氧化脂质类
Abstract： 目的 探讨一氧化氮(NO)超氧化物歧化酶(SOD)和过氧化脂质(LPO)在妊高征发病中的作用.方法 随机选择妊高征患者60例(妊高征组)、正常晚期妊娠妇女30例(正常妊娠组)、正常非妊娠妇女30例(对照组),分别采用Greiss反应法、放射免疫法和荧光测定法测定血清NO、SOD和LPO水平.结果 正常妊娠组血清NO、SOD和LPO及NO/LPO比值均明显高于对照组(P＜0.001;P＜0.01),但SOD/LPO比值无显著差异(P＞0.05).妊高征组血清NO/LPO比值和SOD/LPO比值明显降低(P＜0.001).结论 妊娠期机体氧化和抗氧化平衡失调及NO合成减少可能与妊高征的发病过程有关.
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